CEREBRAL EMBOLIC EVENTS

Cerebral emboli are commonly associated with left-sided cardiac procedures. During cardiovascular procedures, debris from the aortic valve, ascending aorta and other sources may embolize and cause cerebral infarction. Cerebral damage may not be clinically evident after cardiovascular procedures and can take months or years for symptoms to manifest. However, embolic brain lesions can be objectively and consistently detected by diffusion-weighted magnetic resonance imaging (DW MRI).

Clinical Manifestations

Acute Manifestations in Context
During cardiovascular procedures, debris from the aortic valve, ascending aorta and other sources may embolize and cause cerebral infarction. Embolic brain lesions may lead to potentially devastating outcomes — stroke, dementia and cognitive decline.

INCIDENCE OF NEW BRAIN
LESIONS BY NEURO-IMAGING

INCIDENCE OF SYMPTOMATIC
STROKE

incidence of new brain incidence of symptomatic
*Knipp 2005, Stolz 2004. **Astarci 2011, Ghanem 2010, Kahlert 2010, Rodés-Cabau 2011.

Clinical Evidence - Neurocognitive Decline 3 Months

Post operative cognitive decline was detected on 2 of 10 neuropsychological tests (total recall and non-verbal for memory) for the catheterization group (n=33) and 7 of 10 tests for the CABG group (n=47)


The TriGuard Cerebral Protection Device is not commercially available in the USA.