December 03, 2018 Current Cerebral Embolic Protection Landscape

Keystone Heart TriGUARD Data Review

Jeffrey Moses

Conclusions:

• Overt and Covert stroke are significant complications of TAVR which may be of greater consequence as we move in to lower risk, younger populations
• The weight of evidence indicates that CEP reduces these events
• By covering al 3 cerebral vessels TriGuard cerebral embolic protection may further reduce risk form that seen in SENTINEL
• TriGuard cerebral protection is safe and does not add procedural risk
• Phase 2 of REFLECT is underway and hopefully will give us definitive evidence of clinical efficacy