Keystone Heart is focused on protecting the brain from emboli to reduce the risk of brain infarcts during TAVR.
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Abstracts | Manuscripts

Abstracts | Manuscripts

Abawi M, Nijhoff F, Agostoni P, et al. Incidence, predictive factors, and effect of delirium after transcatheter aortic valve replacement. J Am Coll Cardiol Intv. 2016;9:160-168. Abstract.

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AP Kappetein et al. Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document. Eur Heart J. 2012 Oct;33(19):2403-18. doi: 10.1093/eurheartj/ehs255. Abstract. Full Text.

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Bagienski M, Kleczynski P, Dziewierz A, et al. Incidence of postoperative delirium and its impact on outcomes after transcatheter aortic valve implantation. Am J Cardiol.2017; Epub ahead of print. Abstract. Full Text.

Baumbach, A, et al. Safety and performance of a novel embolic deflection device in patients undergoing transcatheter aortic valve replacement: results from the DEFLECT I study. EuroIntervention. 2015 May;11(1):75-84.

Bendszus M, Stoll G. Silent cerebral ischaemia: hidden fingerprints of invasive medical procedures. Lancet Neurol. 2006 Apr;5(4):364-72. Abstract. Full Text.

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Campbell et al. The infarct core is well represented by the acute diffusion lesion: sustained reversal is infrequent. J of Cerebral Blood Flow & metabolism 2012;32:50-56. Abstract. Full Text.

Connolly SJ, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009 Sep 17;361(12):1139-51. doi: 10.1056/NEJMoa0905561. Epub 2009 Aug 30. Abstract. Full Text.

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Dangas, G.; Giustino, G. Art and Science of Cerebrovascular Event Prevention After Transcatheter Aortic Valve Replacement. Circ Cardiovasc Interv. 2016 Sep;9(9). pii: e004307. doi: 10.1161/CIRCINTERVENTIONS.116.004307. Abstract. Full Text.

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Eggebrecht H, Schmermund A, Voigtlander T, et al. Risk of stroke after transcatheter aortic valve implantation (TAVI): a meta-analysis of 10,037 published patients. EuroIntervention 2012;8:129-38. Abstract. Full Text.

Erdoes G, Basciani R, Huber C, et al. Transcranial Doppler-detected cerebral embolic load during transcatheter aortic valve implantation. Eur J Cardiothorac Surg 2012;41:778-84. Abstract. Full Text.

Fairbairn TA, Mather AN, Bijsterveld P, et al. Diffusion-weighted MRI determined cerebral embolic infarction following transcatheter aortic valve implantation: assessment of predictive risk factors and the relationship to subsequent health status. Heart 2012;98:18-23. Abstract. Full Text.

Feldman TE, Reardon MJ, Rajagopal V, et al. Effect of mechanically expanded vs self-expanding transcatheter aortic valve replacement on mortality and major adverse clinical events in high-risk patients with aortic stenosis: t. The REPRISE III randomized clinical trial. JAMA. 2018;319:27-37.

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Ghanem A, Muller A, Nahle CP, et al. Risk and fate of cerebral embolism after transfemoral aortic valve implantation: a prospective pilot study with diffusion-weighted magnetic resonance imaging. J Am Coll Cardiol 2010;55:1427-32. Abstract. Full Text.

Gress DR. The problem with asymptomatic cerebral embolic complications in vascular procedures: what if they are not asymptomatic? J Am Coll Cardiol 2012;60:1614-6. Abstract. Full Text.

Giustino G, Sorrentino S, Mehran R, Faggioni M, Dangas G. et al. Cerebral Embolic Protection During TAVR: A Clinical Event Meta-Analysis. J Am Coll Cardiol. 2017 Jan 31;69(4):465-466. doi: 10.1016/j.jacc.2016.12.002. Abstract. Full Text.

Haussig S, et al. Effect of a Cerebral Protection Device on Brain Lesions Following Transcatheter Aortic Valve Implantation in Patients With Severe Aortic StenosisThe CLEAN-TAVI Randomized Clinical Trial. JAMA. 2016;316(6):592–601

Hermann H. Is Cerebral Embolic Protection During Transcatheter Aortic Valve Replacement Beneficial? NEJM Journal Watch editorial 2018; Jan 24

Holmes DR, et al. Annual Outcomes With Transcatheter Valve Therapy: From the STS/ACC TVT Registry. Ann Thorac Surg. 2016 Feb;101(2):789-800. Abstract. Full Text.

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Kahlert P, Al-Rashid F, Doettger P, et al. Cerebral Embolization During Transcatheter Aortic Valve Implantation: A Transcranial Doppler Study. Circulation 2012. Abstract. Full Text.

Kahlert P, Knipp SC, Schlamann M, et al. Silent and apparent cerebral ischemia after percutaneous transfemoral aortic valve implantation: a diffusion-weighted magnetic resonance imaging study. Circulation 2010;121:870-8. Abstract. Full text.

Kahlert P, Knipp SC, Schlamann M, et al. Silent and apparent cerebral ischemia after percutaneous transfemoral aortic valve implantation: a diffusion-weighted magnetic resonance imaging study. Circulation 2010;121:870-8. Abstract. Full Text.

Kapadia S, Kodali S, Makkar R, et al. Protection Against Cerebral Embolism During Transcatheter Aortic Valve Replacement. Journal of the American College of Cardiology Jan 2017, 69 (4) 367-377; DOI: 10.1016/j.jacc.2016.10.023 Abstract.

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Kroon, Need for Embolic Protection During Transcatheter Aortic Valve Implantation: An Interventionalist’s Perspective on Histopathology Findings. ICR 2017 12:1 Issue. Abstract.

Kwok CS, Loke YK, Hale R, Potter JF, Myint PK. Atrial fibrillation and incidence of dementia: a systematic review and meta-analysis. Neurology. 2011 Mar 8;76(10):914-22. doi: 10.1212/WNL.0b013e31820f2e38. Abstract. Full Text.

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Lansky AJ, Messe SR, Brickman AM, et al. Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative. J Am Coll Cardiol 2017;69:679-691. Abstract. Full Text.

Lansky AJ, Schofer J, Tchetche D, et al. A prospective randomized evaluation of the TriGuard HDH embolic DEFLECTion device during transcatheter aortic valve implantation: results from the DEFLECT III trial. Eur Heart J 2015. Abstract. Full Text.

Lansky AJ, et al. Neurologic Complications of Unprotected Transcatheter Aortic Valve Implantation (from the Neuro-TAVI Trial),  American Journal of Cardiology 2017;118 (10):1519–1526. Abstract.

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Lin PJ, Neumann PJ. The economics of mild cognitive impairment. Alzheimers Dement 2013;9:58-62. Abstract. Full Text.

Masieh Abawi, Ermela Yzeiraj; Adriaan Kraaijeveld; Michiel Voskuil,; Pieter A. Doevendans; Joachim Schofer; Pieter R. Stella TriGuard Device for Cerebral Embolic Protection During Transcatheter Aortic Valve Replacement: A Multicenter Real-World Experience. Abstract. Full Text.

Mastoris I, Schoos MM, Dangas GD, et al. Stroke after transcatheter aortic valve replacement: incidence, risk factors, prognosis, and preventive strategies. Clin Cardiol 2014;37:756-64. Abstract. Full Text.

Matteo PagnesiDamiano RegazzoliMarco B. AnconaAntonioMangieriGiuseppe LanzilloFrancesco GianniniNicola BuzzattiBernard D. PrendergastSusheel KodaliAlexandra J. LanskyAntonio ColomboAzeem LatibCerebral Embolic Risk During Transcatheter Mitral Valve Interventions. 

Messe SR, Acker MA, Kasner SE, et al. Stroke after aortic valve surgery: results from a prospective cohort. Circulation 2014;129:2253-61. Abstract. Full Text.

Miller DC, Blackstone EH, Mack MJ, et al. Transcatheter (TAVR) versus surgical (AVR) aortic valve replacement: Occurrence, hazard, risk factors, and consequences of neurologic events in the PARTNER trial. J Thorac Cardiovasc Surg 2012;143:832-843 e13. Abstract. Full Text.

Nishimura RA, Otto CM, Bonow RO, et al. 2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2017 Jun 20;135(25):e1159-e1195. doi: 10.1161/CIR.0000000000000503. Epub 2017 Mar 15. Abstract.

Ogawa M, Izawa KP, Satomi-Kobayashi S, Tsuboi Y, Komaki K, et al. (2017) Impact of delirium on postoperative frailty and long term cardiovascular events after cardiac surgery. PLOS ONE 12(12): e0190359. Full Text.

Pagnesi M, Martino EA, Chiarito M, et al. Silent cerebral injury after transcatheter aortic valve implantation and the preventive role of embolic protection devices: A systematic review and meta-analysis. Int J Cardiol 2016;221:97-106. Abstract. Full Text.

Popma JJ, Adams DH, Reardon MJ, et al. Transcatheter Aortic Valve Replacement Using a Self-Expanding Bioprosthesis in Patients With Severe Aortic Stenosis at Extreme Risk for Surgery. J Am Coll Cardiol 2014;63:1972-81. Abstract. Full Text.

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Seeger J, Gonska B, Otto M, Rottbauer W, Wöhrle J. Cerebral Embolic Protection During Transfemoral Aortic Valve Replacement Significantly Reduces Death and Stroke Compared With Unprotected Procedures. JACC: Cardiovascular Interventions Sep 2017, 3303; DOI: 10.1016/j.jcin.2017.06.037.

Seeger J et al. Cerebral embolic protection during transcatheter aortic valve replacement significantly reduces death and stroke compared with unprotected procedures. JACC Cardiovasc Interv 2017 Nov 27;10:2297 Abstract.

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Stolz E, Gerriets T, Kluge A, et al. Diffusion-weighted magnetic resonance imaging and neurobiochemical markers after aortic valve replacement: implications for future neuroprotective trials? Stroke 2004;35:888-92. Abstract. Full Text.

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